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	Preparation of expression vector for production of receptors CD69 and S1P1 Leontovyč, Adrian ; Vaněk, Ondřej (advisor) ; Obšil, Tomáš (referee) T- and B- lymphocytes play a key role in immunity, because they provide specific immunity in organism. Receptor S1P1 regulates lymphocyte egress from lymphoid organs to blood, from which the lymphocytes travel to the site of infection. It was discovered that transmembrane helix 4 of S1P1 receptor interacts with transmembrane part of CD69 receptor and this interaction is responsible for retention of lymphocytes in lymphoid organs. The aim of this study is to prepare expression plasmids for production of these two receptors and their further research. Detailed record
	The role of sphingosin kinase in cardioprotection Pospíšilová, Barbora ; Nováková, Olga (advisor) ; Kolář, David (referee) Sphingosine-1-phosphate (S1P) is bioactive mediator with cardioprotective effect. Sphingosine kinase (SK) is a key enzyme in the synthesis of S1P. It exists in the two isoforms sphingosine kinase 1 and sphingosine kinase 2. Although SK1 has antiapoptotic feature and SK2 has proapoptotic feature both are crucial for the effect of S1P. S1P can act and affect the cellular faith by intracellular or extracellular functioning. Extracellular S1P binds and activates specific cell surface receptors on the plasma membrane. These receptors are members of the group of G protein-coupled receptors. There are tree subtypes of S1P receptors in the heart tissue (S1P1, S1P2, S1P3). Exogenous S1P increases viability of cardiomyocytes after myocardiacal ischemia/reperfusion injury (I/R). It also reduces the infarct size in isolated rat heart. During conditions of ischemic preconditioning (IPC) or postconditioning (IPOST) which consist of the short periods of ischemia before or after major ischemia insult generate S1P. Released S1P increased viability of the cell and faster recovery of hemodynamic functions in the heart tissue. Effects of S1P and its role in cardioprotection are explored in the genetically modified organisms mainly in the mouses. The evidence of the cardioprotective effect of S1P were experiments using... Detailed record
	Preparation of expression vector for production of receptors CD69 and S1P1 Leontovyč, Adrian ; Vaněk, Ondřej (advisor) ; Obšil, Tomáš (referee) T- and B- lymphocytes play a key role in immunity, because they provide specific immunity in organism. Receptor S1P1 regulates lymphocyte egress from lymphoid organs to blood, from which the lymphocytes travel to the site of infection. It was discovered that transmembrane helix 4 of S1P1 receptor interacts with transmembrane part of CD69 receptor and this interaction is responsible for retention of lymphocytes in lymphoid organs. The aim of this study is to prepare expression plasmids for production of these two receptors and their further research. Detailed record

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